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Schoolbag is based on the Schoolbag item from the mod Antibirth, and it is the only item from that mod to be added to the Binding of Isaac before the Repentance dlc.Schoolbag's appearance prior to Booster Pack #5.
This does not apply to other sources of invincibility.
If one Curse of the Labyrinth is encountered, getting to ? and entering the Shop there will unlock the Schoolbag.This item cannot be unlocked if the player encounters more than one Curse of the Labyrinth in Chapters 1-3, except by chance of finding Silver Dollar, Forget Me Now, or a 5-pip Dice Room.The swap key must be pressed twice if playing as The Forgotten.If this happens, Isaac can swap the bonus-granting item to the pedestal and pick it up again to regain them. While holding an active item that grants passive bonuses in the secondary slot, swapping the main slot item with a pedestal item may remove the bonuses.The ? Card does not activate both active items.Items that grant temporary effects for the room, such as The Nail, may deactivate if switched with an item in the secondary slot.Items in the secondary slot will recharge at the same rate as the primary item.The button to swap between active items is the same button used to swap between cards and pills.
Swap between active items by pressing the PC Control key, PS4 R2, XboxOne RT, or Switch ZR.